Poly Pharm. has successfully developed Salidroside (Scientific name 2-(4-hydroxyphenyl) ethyl-β-D-glucopyranoside), a raw material for drugs, cosmetics and health care products, through synthetic biology technology. The product is obtained by fermentation of genetically engineered strains of bacteria, and the purity reaches more than 98%.At present, the company has completed the registration of submission (API submission code 002880-00575-6466), and is able to meet the requirements of external supply of kilogram samples.
Salidroside is the main active substance of the precious Chinese and Tibetan drug product Rhodiola Rosea, which has significant multiple effects such as antioxidant, anti-fatigue, anti-radiation, and enhancement of human function. Some pharmacological studies have shown that salidroside achieve immunomodulation by improving cellular antioxidant capacity, scavenging reactive oxygen species, regulating inflammatory cytokine expression and inhibiting the synthesis of inflammatory mediators. Due to its significant effect in anti-aging and cardiovascular protection, it is widely used in the fields of drugs (such as Lianhua Qingwen capsule, etc.), skin care products (such as France SEPHORA, Inoherb, etc.), health care products and dietary supplements (such as the U.S. Now Foods, GNC, etc.).Salidroside are mainly found in the tuberous roots of Rhodiola rosea, which is regarded as "plateau ginseng". Due to the long cultivation period and high cost of Rhodiola rosea, the extraction of Salidroside from plants not only greatly consumes the natural resources of Rhodiola rosea, but also a large number of organic solvents extracted from the plant is easy to cause environmental pollution, and the residue of impurities harmful to humans in the product (such as thymoquinone). Although chemical synthesis can reduce the consumption of natural resources in Rhodiola rosea plants, it often leaves small amounts or traces of other toxic chemicals and is accompanied by serious environmental pollution problems.
In 2021, China's Rhodiola rosea extract production in about 1,100 tons, of which the demand for rhodiola rosea glycoside is close to 250 tons, only in the cosmetic market of about 100 million yuan of sales per year. In the field of health care products has a wider application market of about 1.5~2 billion yuan sales per year, and exported to the United States and Europe. In recent years, it is found that salidroside have good therapeutic effect on cardiovascular, asthma and gouty arthritis, and the market potential is expanding, with good market prospects.
The synthetic biology R&D platform of Poly uses saccharomyces cerevisiae, which is internationally recognized for its extremely high biosafety, as the chassis cell. Heterologous synthesis of products by reconfiguration of the Salidroside biosynthetic pathway, combined with optimization of the metabolic network regulatory pathway to achieve high yields of target products. While realizing the microbial synthesis of Salidroside, the platform further made breakthroughs in the modification of key enzymes by enzyme engineering and the blocking of by-product branching pathways by gene editing. Effectively improved the production level of Salidroside and greatly reduced the content of impurities, realizing the successful mass production of Salidroside from glucose. At present, the process development and product quality research have been completed, realizing the stable supply of Salidroside above the kilogram level with high purity, high quality and high safety.Salidroside is one of the products researched and developed by Poly biological R&D platform. This R&D platform focuses on synthetic biology technology, realizes the biomanufacturing of high value-added active products and important pharmaceutical intermediates, and empowers the original research and innovation of the biopharmaceutical industry.Poly Pharm. will continue to implement the global strategy of "Advanced High-end Manufacturing, Facing Domestic and International", and continue to research and develop more and better drug products. and make drug products, cosmetics and healthcare ingredients with the pharmaceutical rigor and professionalism!
