Retinol is one of the most potent active molecules in anti-aging formulations of cosmetics and is highly regarded by skin care professionals and consumers worldwide. It has been shown in some studies to improve pores, fine lines, wrinkles, dark spots, and so on.
In recent years, with the trend of "Morning C, Evening A" skin care, retinol is currently known and recognized by the majority of consumers.
1）Retinol properties are unstable; Poly Pharm. manufactures retinol using the esterolysis method, with short process route and simple operation, which shortens the stay time of the product in the production process, effectively ensures product quality, and control the appearance in the ideal light yellow transparent state;
2）Strict in-house quality specifications for the residual solvents of Retinol manufactured by Poly Pharm. have been established; the appearance is well without odor;
3）The Retinol production process of Poly Pharm. is managed according to the cGMP standards under GMP conditions, therefore the retinol purity is higher, impurities are less, and the product quality is stable and reliable;
4）After adding stabilizer, it has high stability, long shelf life and easy preservation;
5）Conduct a variety of efficacy experiments for a long time, support customer promotion.
1）Stable supply；
2）Annual capacity up to 15 tons。
When the concentration of Poly retinol is 0.0005%, the inhibition rate of melanin synthesis is about 52.20±2.39% (P < 0.05).
The results show that retinol has excellent inhibition of melanin synthesis in B16 cells at low concentration.
When the concentration is 0.00625%, the inhibition rate of tyrosinase monophenolase activity is 43.34±0.34%.
It is demonstrated that retinol has good inhibition ability on tyrosinase activity, and certain whitening effect.
The anti-wrinkle effect experiment of retinol: When the concentration of retinol is 0.001%, the corresponding up-regulation rate of type I collagen is about 14.59±1.38% (p < 0.05).
Note: TGF-β1 = transforming growth factor β1
It is proved that the synthesis of type I collagen in dermal fibroblasts is significantly up-regulated.
When the concentration of retinol is 1%, the corresponding DPPH clearance rate (%) is about 86.72±0.26% (P < 0.001).
It is proved that retinol has good scavenging ability for DPPH free radicals and good antioxidant ability, which is close to ascorbic acid
When the concentration of Poly retinol is 0.00195%, the inhibition rate of NO is 55.93±1.70% (P < 0.001).
When the concentration of Poly retinol is 0.001%, the inhibition rate of NO is 33.50±1.30% (P < 0.001).
It is proved that Poly retinol has a better ability to inhibit the release of NO in Raw264.7 cells, and can play an excellent soothing effect.
